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LCA11

IMPDH1

Inosine monophosphate dehydrogenase; essential for nucleotide biosynthesis

No Targeted Treatment Yet

Chromosomal Locus

7q32.1

Inheritance

Autosomal Dominant

Frequency

~5% of LCA cases

OMIM #613837

Key Clinical Features

  • 1Autosomal dominant inheritance
  • 2Nucleotide metabolism disruption in photoreceptors

Sources: