Back to All TypesOMIM #612712
LCA13
RDH12
Retinol dehydrogenase; part of the visual cycle, converts all-trans-retinal
Preclinical Research
Opus Genetics OPGx-RDH12 in partnership with Global RDH12 Alliance. IND filing planned late 2025, first patient expected Q4 2026.
Chromosomal Locus
14q24.1
Inheritance
Autosomal Recessive
Frequency
~10% of LCA cases
Key Clinical Features
- 1LCA phenotype with significant disease progression in adolescence
- 2Early, peripherally progressive macular atrophy with watercolor-like pattern