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WhatIsLCA
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LCA14

LRAT

Lecithin retinol acyltransferase; essential for the visual cycle (same pathway as RPE65)

No Targeted Treatment Yet

Sourced & cited — not yet expert-reviewed

Every statement here is backed by a cited primary source, but a specialist has not formally reviewed this page yet.

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Chromosomal Locus

4q32.1

Inheritance

Autosomal Recessive

Frequency

<1% of LCA cases

OMIM #613341

Key Clinical Features

  • 1Visual cycle defect (similar pathway to RPE65)
  • 2Severe early visual loss
  • 3Potential gene therapy target

Sources: