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WhatIsLCA
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LCA15

TULP1

Tubby-like protein; involved in photoreceptor protein transport

Preclinical Research

No clinical trial or company program. Early academic proof-of-concept: AAV-delivered Tulp1 supplementation was tested in Tulp1-knockout mice but provided only limited benefit, indicating better delivery strategies are still needed (Palfi et al., Frontiers in Neuroscience 2020).

Sourced & cited — not yet expert-reviewed

Every statement here is backed by a cited primary source, but a specialist has not formally reviewed this page yet.

Chromosomal Locus

6p21.31

Inheritance

Autosomal Recessive

Frequency

<1% of LCA cases

OMIM #613843

Key Clinical Features

  • 1Photoreceptor protein transport defect
  • 2Progressive photoreceptor degeneration